Arias Had No Remorse: Prosecutor

Prosecutor Juan Martinez hammered alleged murderer Jodi Arias today with accusations that she felt no remorse when she lied over and over again about killing her ex-boyfriend, Travis Alexander.

"Ma'am you have a problem with telling the truth don't you?" Martinez asked as his first question today, the 11th day Arias has been on the stand explaining her role in Alexander's death.

"Not typically," Arias responded.

Martinez then took Arias through a series of lies she admittedly told in the days after she stabbed and shot Alexander to death on June 4, 2008, lying to friends, investigators and even Alexander's grandmother, going so far as to send a dozen irises to his grandmother expressing her sympathy.

See the Evidence in the Jodi Arias Murder Trial

Arias, 32, has testified that she killed Alexander in self-defense during a violent argument and lied about it out of "shame."

But prosecutors say that the 27 stab wounds, a slashed throat, and two bullets she fired at Alexander's head prove that she murdered him. She could face the death penalty if convicted.

Catching Up on the Trial? Check Out ABC News' Jodi Arias Trial Coverage

Today Martinez tried to raise doubts about Arias' earlier testimony in which she depicted Alexander as an increasingly menacing and sexually demanding lover by grilling her about the lies she told after she killed Alexander.

Martinez pointed out that Arias lied to Detective Esteban Flores of the Mesa, Ariz., police department as he investigated Alexander's death. She initially denied to the detective that she was at Alexander's Mesa, Ariz., home when he was killed, and later said he was murdered by a pair of masked intruders.

Jodi Arias Testimony: Prosecution's Cross-Examination Watch Video

Jodi Arias Remains Calm Under Cross-Examination Watch Video

Jodi Arias Doesn't Remember Stabbing Ex-Boyfriend Watch Video

"You told (Flores) you would help him, but that was a lie right? You weren't there to tell the truth. You were there for another purpose: to make sure he didn't get the truth.... You were hoping, ma'am, that (Flores) would believe what you were saying so you could walk out of jail," Martinez said.

Arias argued with Martinez, claiming that she lied to investigators out of shame, and lied to friends immediately after the death out of confusion.

"My mind wasn't right during all that period," Arias said referring to the hours immediately following the killing when she drove through the Arizona desert and made phone calls to ex-boyfriend Matthew McCartney and new love interest Ryan Burns.

"It's like I wasn't accepting it in my mind... because I never killed anyone before," she said.

Martinez also suggested that Arias tried to find out the status of the investigation into Alexander's death so that she could know if she were about to be arrested. When a friend of Alexander's called her to report the news about Alexander's death, Arias asked about details into the investigation, the prosecutor said. She also called Alexander's Mormon bishop and asked him what he knew about the case, and then asked friends and family members what they knew, according to Martinez.

"You needed to see what you needed to know to make sure you weren't charged. What purpose would there be for that information other than to benefit you?" Martinez asked. "You called [the bishop] at 3 a.m. You call him and spoke to him because you wanted to get the information about what he knew about the investigation. That was going to help you."

Timeline of the Jodi Arias Trial

Martinez also went over lies that Arias told to her friend, Leslie Udy, and Ryan Burns, both of whom she saw in Utah the day after killing Alexander. She talked to both about Alexander as if he were still alive. Martinez pointed out that Arias even made out with Burns in his bedroom during their visit.

But Arias claimed that it was Burns who lied about their encounter.

"And with Mr. Burns, didn't you get on top of him and grind on him?" Martinez asked.

Arias said she was on top of Burns at one point, but they did not "grind."

"Well, when you were romantic kissing, he did put his hand between your legs, didn't he?" Martinez said, referring to Burns' own testimony in court weeks earlier.

"No," Arias said. "It could be that he's full of crap...when he says he got near my vaginal area."

"This is the person who lied to him, to (friends), to Detective Flores, and yet you're telling us someone else is full of crap," Martinez asked incredulously.

"When it comes to that, yes," she said.

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Syrian opposition says captures former nuclear site

AMMAN (Reuters) - Syrian rebels have captured the site of a suspected nuclear reactor near the Euphrates river which Israeli warplanes destroyed six years ago, opposition sources in eastern Syria said on Sunday.

Al-Kubar site, around 60 km (35 miles) west of the city of Deir al-Zor, became a focus of international attention when Israel raided it in 2007. The United States said the complex was a North Korean-designed nuclear reactor geared to making weapons-grade plutonium.

Omar Abu Laila a spokesman for the Eastern Joint Command of the Free Syrian Army said the only building rebels found at the site was a hangar containing at least one Scud missile.

"It appears that the site was turned into a Scud launch base. Whatever structures it had have been buried," he said, adding that three army helicopters airlifted the last loyalist troops before opposition fighters overran the area on Friday.

The Syrian military, which razed the site after the Israeli raid, said the complex was a regular military facility but refused to allow the International Atomic Energy Agency unrestrained access, after the agency said the complex could have been a nuclear site.

The U.N. investigation appears to have died down since the national revolt against Preident Bashar al-Assad broke out in 2011, with the armed opposition increasingly capturing military sites in rural areas and on the edges of cities.

U.N. inspectors examined the site in June 2008 but Syrian authorities has barred them access since.

Abu Laila said Scuds appear to have been fired from Kubar at rebel-held areas in the province of Homs to the west.

The complex, he said, had command and control links with loyalist troops in the city of Deir al-Zor, where Assad's forces have been on the retreat and are now based mainly in and around the airport in the south of the city.

Footage showed fighters inspecting the site and one large missile inside a hangar. One fighter pointed to what he said were explosives placed under the missile to destroy it before attacking forces got to it.

Abu Hamza, a commander in the Jafaar al-Tayyar brigade, said in a YouTube video taken at Kubar that various rebel groups, including the al Qaeda linked al-Nusra front, took part the operation and that U.N. inspectors were welcome to come and survey the site.

In the last few months, opposition fighters have captured large swathes of the province of Deir al-Zor, a Sunni Muslim desert oil producing region that borders Iraq, including most of a highway along Euphrates leading to Kubar.

The province is far from the Assad's main military supply bases on the coast and in Damascus. Long-time alliances between Assad, who belongs to the minority Alawite sect, an offshoot of Islam, and Sunni tribes in Deir al-Zor have also largely collapsed since the revolt.

But Assad's forces remain entrenched in the south of the city of Deir al-Zor and armed convoys guarded by helicopters still reach the city from the city of Palmyra to the southwest, according to opposition sources.

(Editing by Stephen Powell)

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Brazil cardinal suggests church look to Latin America

APARECIDA: Catholicism in Latin America is "lively and dynamic," Brazilian Cardinal Raymundo Damasceno Assis said Sunday, suggesting that the church look to Latin America for leadership.

Damasceno is one of the 117 "cardinal electors" that will participate in the upcoming conclave to elect a new pope. No favourite has to succeed Pope Benedict XVI, who announced that he is stepping down at the end of the month.

The 76 year-old Damasceno, who is also head of Brazil's Conference of Catholic Bishops, told AFP in a phone interview that, unlike in Europe, the faith is strong in Latin America.

"The church in Latin America is enjoying a very special moment, with strong missionary enthusiasm," Damasceno told AFP.

That enthusiasm serves to bolster flagging interest for Catholicism in Europe, a region "undergoing a very intense process of secularisation and that suffers from a crisis of religious vocations."

Openly campaigning for the papacy is taboo, but cardinals discreetly drop hints about their preferences.

Brazilian bishops believe that it is "fundamental" for the next pope to be a person who is a pastoral figure, Damasceno said, "open to dialog with the contemporary world and sensitive to social problems."

Damasceno, himself a candidate, is one of five Brazilians who will be at the conclave. They include Odilo Scherer, 63, who was ordained by Benedict in 2007 and heads the five million strong archdiocese of Sao Paulo, and Salvador archbishop Geraldo Majella Agnelo, 79.

Brazil has the most Catholics in the world, but in recent years evangelical and Protestant churches have made considerable inroads, especially among the poor.

- AFP/jc

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Riyaz Bhatkal: Shy student to terror mastermind

MUMBAI: Seventeen-year-old Riyaz Shahbandri from Kurla was a shy civil engineering student at Nagpada's Saboo Siddik polytechnic in 1993. He would maintain a low profile and hardly participated in any college events. However, girls found his chocolate-boy looks appealing. Two decades later, he began making headlines as Riyaz Bhatkal, a suspected terrorist who has killed more people than the feared Dawood Ibrahim or the hanged Pakistani terrorist Ajmal Kasab—more than 344 killed from 15 bomb blasts. Still elusive, today he is the most dreaded face of the banned terror outfit Indian Mujahideen.

Born in 1976 as Riyaz Ismail Shahbandri in Bhatkal village of Karnataka, he came to be known as Roshan Jamal, while staying at the 60-year-old, two-storey building Qadir Mansion in Kurla here. Today his family owns two rooms in the building, which have been rented out as they wanted to stay away from the police who would often land up at their place inquiring about his whereabouts. His father, Ismail, had shifted from Karnataka to Mumbai for setting up a purse-making business much before Riyaz was born. Despite obtaining a degree in civil engineering, Riyaz couldn't find a job and began helping his father in his business. By then, his elder brother Iqbal had joined a local developer's firm as a civil engineer.

In 2001, Riyaz fell in love with a girl from Kurla but his family disapproved of the relationship and he was finally married to Nashua, the daughter of a Bhatkal-based businessman. A few months before his wedding, he came in touch with the Kurla unit of Students' Islamic Moment of India (SIMI). When he became a member of the outfit, it was already divided into two factions, extremists and the moderates. Riyaz preferred to stay with the first group. While the outfit was banned and its members arrested, he managed to evade the police. Soon he started preaching the SIMI ideology and was considered as a key figure among his associates. At the same time, Riyaz came in touch with local goons and started extorting money from traders in order to fund the activities of SIMI. "In 2002, he allegedly gave supari to kill the owner of Deepak Farsan in Kurla. The shooters killed the owner's bodyguard and Riyaz was never arrested," said an investigator of the case.

A city crime branch official said, "A year later, he entered Pakistan illegally and got training in operating fire arms and assembling explosives at a Lashkar-e-Taiba (LeT) camp. In 2004, along with Atif Ameen (who was later killed in the Batla House encounter in 2008), Sadiq Asrar Shaikh (who is behind bars in Mumbai), Subhan Qureishi alias Tauqeer and Yasin Bhatkal (both absconding), he conducted his first training for Indian men at Jolly Beach, a farm house in Bhatkal. Yasin, though hailing from Bhatkal, is not related to Riyaz. In 2005, the quintet executed their first terror blast at Sankat Mochan temple in Uttar Pradesh. While Riyaz provided the explosives, Tauqeer and Shaikh recruited the men. This was the time the group decided to name itself Indian Mujahideen (IM). Cops were unaware of its existence. Iqbal too had got influenced by the extremist ideology. He was one of the founder members of the IM.

"Soon after executing the bombings at the court premises in Lucknow, Varanasi and Faizabad on November 23, 2007, IM sent its first email to a news channel, claiming responsibility," the charge sheet on these blasts reads. In 2008, IM carried out bombings in Bangalore and Ahmedabad and for the first time Riyaz's name cropped up during the probe. He had conducted a seven-day training session for new recruits at Bhatkal prior to the blasts." After police started visiting Bhatkal frequently in search of him, Riyaz escaped to Pakistan in 2008 via Bangladesh. That was the last time his family saw him," a senior ATS officer added. Meanwhile, his father was last spotted in Mumbai on April 16, 2008, when he had gone to collect rent for his two rooms in Qadir Mansion.

In March 2010, Riyaz travelled to Colombo and met Yasin Bhatkal, Mohsin Chaudhry and Mirza Himayat Bain to plan Pune's German Bakery bomb blast. In July 2011, a red corner notice was issued against Riyaz in connection with the 2008 Bangalore blast. The chargesheet in Mumbai's July 13, 2011, triple blast cases said that "the entire criminal conspiracy was hatched by Riyaz and Yasin Bhatkal", who are "the chief cogs of the notorious" IM. The banned terrorist group, it adds, was created by Pakistani spy agency ISI "to spread terror in India". Riyaz and his brother Iqbal Bhatkal "operate from Pakistan" and impart instructions via electronic means to their associates based here through Yasin. According to forensic reports, Trinitrotoluene (TNT), ammonium nitrate and petroleum oil were used in the Mumbai bomb blasts.

This is the story as narrated by Riyaz's proteges, neighbors, friends and police. However, no one knows Riyaz's side of the story.

Riyaz Bhatkal's bloody trail:

Oct 29, 2005: Paharganj, Sarojini Nagar and Gopal Nagar in Delhi, killed 62

March 7, 2006: Sankat Mochan temple, Kashi Viswanath temple in Varanasi, killed 28

Nov 24, 2006: Faizabad, Lucknow and Varanasi courts

May 25, 2007: Gorakhpur market

Aug 25, 2007: Lumbini Park and Gokul Chat in Hyderabad, killed 42

May 23, 2008: Jaipur, killed 80

July 24, 2008: Bangalore, killed 02

July 25, 2008: Ahmedabad serial explosions, killed 56

July 26, 2008: Surat (bombs defused)

Sept 13, 2008: Delhi, killed 30

Feb 13, 2010: Pune German Bakery blast, killed 17

July 13, 2011: Mumbai triple blasts, killed 27

August 1, 2012: Pune serial bomb blasts

Total killed: 344

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FDA approves new targeted breast cancer drug

WASHINGTON (AP) — The Food and Drug Administration has approved a first-of-a-kind breast cancer medication that targets tumor cells while sparing healthy ones.

The drug Kadcyla from Roche combines the established drug Herceptin with a powerful chemotherapy drug and a third chemical linking the medicines together. The chemical keeps the cocktail intact until it binds to a cancer cell, delivering a potent dose of anti-tumor poison.

Cancer researchers say the drug is an important step forward because it delivers more medication while reducing the unpleasant side effects of chemotherapy.

"This antibody goes seeking out the tumor cells, gets internalized and then explodes them from within. So it's very kind and gentle on the patients — there's no hair loss, no nausea, no vomiting," said Dr. Melody Cobleigh of Rush University Medical Center. "It's a revolutionary way of treating cancer."

Cobleigh helped conduct the key studies of the drug at the Chicago facility.

The FDA approved the new treatment for about 20 percent of breast cancer patients with a form of the disease that is typically more aggressive and less responsive to hormone therapy. These patients have tumors that overproduce a protein known as HER-2. Breast cancer is the second most deadly form of cancer in U.S. women, and is expected to kill more than 39,000 Americans this year, according to the National Cancer Institute.

The approval will help Roche's Genentech unit build on the blockbuster success of Herceptin, which has long dominated the breast cancer marketplace. The drug had sales of roughly $6 billion last year.

Genentech said Friday that Kadcyla will cost $9,800 per month, compared to $4,500 per month for regular Herceptin. The company estimates a full course of Kadcyla, about nine months of medicine, will cost $94,000.

FDA scientists said they approved the drug based on company studies showing Kadcyla delayed the progression of breast cancer by several months. Researchers reported last year that patients treated with the drug lived 9.6 months before death or the spread of their disease, compared with a little more than six months for patients treated with two other standard drugs, Tykerb and Xeloda.

Overall, patients taking Kadcyla lived about 2.6 years, compared with 2 years for patients taking the other drugs.

FDA specifically approved the drug for patients with advanced breast cancer who have already been treated with Herceptin and taxane, a widely used chemotherapy drug. Doctors are not required to follow FDA prescribing guidelines, and cancer researchers say the drug could have great potential in patients with earlier forms of breast cancer

Kadcyla will carry a boxed warning, the most severe type, alerting doctors and patients that the drug can cause liver toxicity, heart problems and potentially death. The drug can also cause severe birth defects and should not be used by pregnant women.

Kadcyla was developed by South San Francisco-based Genentech using drug-binding technology licensed from Waltham, Mass.-based ImmunoGen. The company developed the chemical that keeps the drug cocktail together and is scheduled to receive a $10.5 million payment from Genentech on the FDA decision. The company will also receive additional royalties on the drug's sales.

Shares of ImmunoGen Inc. rose 2 cents to $14.32 in afternoon trading. The stock has ttraded in a 52-wek range of $10.85 to $18.10.

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Pistorius' Brother Facing Own Homicide Trial

The attorney for Oscar Pistorius' family said today that the Olympian's brother is facing a culpable homicide charge relating to a 2008 road accident in which a motorcyclist was killed.

Carl Pistorius, who sat behind his younger brother, Oscar, every day at his bail hearing, will now face his own homicide trial for the accident five years ago, which his attorney, Kenny Oldwage, said he "deeply regrets."

Carl Pistorius is charged with culpable homicide, which refers to the unlawful negligent killing of another person. The charges were initially dropped, but were later reinstated, Oldwage said in a statement.

Full Coverage: Oscar Pistorius Case

Pistorius quietly appeared in court on Thursday, one day before his Paralympic gold-medalist brother was released on bail, Oldwage said. His next appearance is scheduled for the end of March.

Liza van Deventer/Foto24/Gallo Images/Getty Images

'Blade Runner' Murder Charges: Oscar Pistorius Out on Bail Watch Video

Oscar Pistorius Granted Bail in Murder Case Watch Video

It was the latest twist in a case that has drawn international attention, after 26-year-old Oscar Pistorius, a double amputee who ran in both the 2012 Olympic and Paralympic games, was charged with the premeditated murder of his model girlfriend, Reeva Steenkamp.

On Saturday, Carl Pistorius' Twitter handle was hacked, according to a family spokeswoman, prompting the Pistorius family to cancel their social media accounts.

Steenkamp's parents speak about the Valentine's Day shooting that ended their daughter's life in a sit-down interview on South African television tonight.

On Saturday, the model's father, Barry Steenkamp, told the Afrikaans-language Beeld newspaper that Pistorius will have to "live with his conscience" and will "suffer" if his story that he shot Steenkamp because he believed she was an intruder is false.

RELATED: Oscar Pistorius Case: Key Elements to the Murder Investigation

After a four-day long bail hearing, Pistorius was granted bail Friday by a South African magistrate.

The court set bail at about $113,000 (1 million rand) and June 4 as the date for Pistorius' next court appearance.

Pistoriuis is believed to be staying at his uncle's house as he awaits trial. As part of his bail conditions, Pistorius must give up all his guns, he cannot drink alcohol or return to the home where the shooting occurred, and he must check in with a police department twice a week.

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Tens of thousands in Spain protest economic policy, corruption

MADRID (Reuters) - Tens of thousands of Spaniards marched through cities across the country on Saturday to protest deep austerity, the privatization of public services and political corruption.

Gathering under the banner of the "Citizen Tide", students, doctors, unionists, young families and pensioners staged rowdy but non-violent demonstrations as a near five-year economic slump shows no sign of recovery and mass unemployment rises.

"I'm here to add my voice. They're cutting where they shouldn't cut; health, education ... basic services. And the latest corruption scandal is just the tiniest tip of a very large iceberg," said Alberto, 51, an account administrator for a German multinational in Madrid, who preferred not to give his surname.

Protests in Spain have become commonplace as the conservative government passes measures aimed at shrinking one of the euro zone's highest budget deficits and reinventing an economy hobbled by a burst housing bubble.

Prime Minister Mariano Rajoy has introduced some of the deepest budget cuts in Spain's democratic history in an attempt to convince investors the country can weather the economic crisis without falling back on international aid.

But, with more than half of the country's young people out of work and growth not expected until sometime next year, the measures have only scratched the surface of the budget shortfall which is expected to be more than double the target in 2014.

Meanwhile, corruption scandals which have hit the ruling party as well as the once-popular royal family has left many Spaniards disenchanted with their leaders on all sides of the political spectrum.

In Madrid, under a clear, cold winter sky, Saturday's marches convened from four different points by early evening in Neptune Square, between the heavily policed and barricaded parliament, the Ritz Hotel and the stock exchange.

Carrying placards which condemned everything from cuts in the health sector to massive bailouts granted to Spain's banking system, crowds banged drums and chanted, while dozens of riot police stood on the sidelines.

The march coincided with the anniversary of a failed coup attempt in 1981 by Civil Guard officers who stormed Parliament and held deputies hostage until the next day.

(Reporting By Paul Day; Editing by Jason Webb)

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Auto racing: Late crash mars Daytona Nationwide finish

DAYTONA BEACH: A fiery car crash sent Kyle Larson's car airborne and flying debris injured a number of fans Saturday in the waning moments of the NASCAR Nationwide Series season-opener.

The wreck, which occurred almost as Tony Stewart was taking the chequered flag for victory, appeared to begin when Regan Smith was turned sideways and took several competitors behind him in a pack.

Larson, making his first start in the NASCAR stock car second-tier series, then sailed into the catch-fencing.

Larson's car tore a hole in the fence, and his engine sheared off with at least one tire and other debris flying into the stands.

ESPN quoted Daytona Beach police as saying 15 fans were injured, one critically.

"Our prayers and thoughts are with everybody they are working on," NASCAR President Mike Helton said.

Emergency medical personnel immediately went into the stands to treat those hurt, but NASCAR officials could not immediately confirm the number and nature of the injuries. None of the drivers was injured.

"There was obviously some intrusion into the fence, and fortunately with the way the events are equipped, there was plenty of emergency workers ready to go," Helton told ESPN. "They all jumped on it pretty quickly.

"Right now, it's just a function of trying to determine what all damage is done," added Helton, who said some injured fans were being taken to local hospitals.

Another big crash, involving 11 cars, took place with five laps remaining, with driver Michael Annett taken to hospital after hitting a barrier.

"We've always known since racing started this is a dangerous sport," Stewart said. "As much as we want to celebrate, I'm more concerned about the fans and the drivers right now."

- AFP/jc

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Stuck to rubber, terrorists let go of gun

AGARTALA: Ranjit Debbarma still remembers the day 11 years ago when, as an area commander with banned terrorist group NLFT, he trekked for two months -- from the Jampui hills to Rangamurra and then to border areas of Bangladesh before finally reaching Burma -- to carry back Ak 47, 56, M 16 and SK guns for the insurgency back home in Tripura.

Today, though, the 37-year-old can be seen going from one rubber tree to another, collecting latex and talking to his labourers in the plantation at Jarul Bachai, about 13 km from Agartala. His daughter is in an English school and he now wants to buy a motorbike so that it's easier for him to drop her to class every day.

"We were safe in the camps of both Bangladesh and Burma then," the National Liberation Front of Tripura guerrilla says, squinting under an unusually bright February sun. "But I now realize that we were misled. I spent six years of my life carrying arms and collecting protection money from terrified people. We were told Tripura should be for its indigenous people and that even our king has been dispossessed by the Bengalis who came here much after we did. We had taken this falsehood as religion. Rubber is the only thing that matters to me now, my only god."

Tripura's burgeoning rubber trade, which has grown from a cultivable area of just 3500 hectares in 1982 to a massive 57,620 hectares in 2012, has changed the life of Debbarma and hundreds of other former militants like him in Tripura. A senior Rubber Board official puts the number at 754. "I have personally trained 60 of them," he says. "This has been a major rehabilitation effort, and I would go to the extent of saying it helped curb insurgency. People like Debbarma will always be grateful to the CPM government for this, if nothing else."

A state done in by lack of connectivity with the rest of the country and an even greater absence of industry, Tripura has been quick to latch on to rubber, spreading fear in many that the way things are going no one will be cultivating anything else in the near future. "Now it is second only to Kerala in terms of production," says Madhu Chatterjee, who has around 100 kanis (6.25 kanis make a hectare) devoted to the crop. "More than 50,000 farmers are involved in this these days as the returns are very high - a kg goes for Rs 210 on an average and profits can be more than Rs 100 - and the state has just the kind of weather that suits this thing. Even those with very little money can invest in it."

A rubber board official, who doesn't want to be named, says that the government is still reluctant to come clean regarding the names or numbers of former rebels who have either been given money to invest in rubber or have been provided small patches of land. "Most of those who came for training used their nom de guerre and went away leaving behind their nom de guerre," he says, adding, "I think we are better off not knowing who they really were, how many they killed and how many lives they ruined. That was the quid pro quo - give us a new life and we'll leave you in peace."

Back in Debbarma's field, he says he knows at least ten others like him who are leading normal lives, stuck to latex, and working as farmers and plantation managers. "If every government helps terrorists in this way, few will pick up the gun,'' he says. "After all, it is only us poor who because of hunger and penury are easy targets for recruitment. You can brainwash easily a man with no food on his table."

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FDA approves new targeted breast cancer drug

WASHINGTON (AP) — The Food and Drug Administration has approved a first-of-a-kind breast cancer medication that targets tumor cells while sparing healthy ones.

The drug Kadcyla from Roche combines the established drug Herceptin with a powerful chemotherapy drug and a third chemical linking the medicines together. The chemical keeps the cocktail intact until it binds to a cancer cell, delivering a potent dose of anti-tumor poison.

Cancer researchers say the drug is an important step forward because it delivers more medication while reducing the unpleasant side effects of chemotherapy.

"This antibody goes seeking out the tumor cells, gets internalized and then explodes them from within. So it's very kind and gentle on the patients — there's no hair loss, no nausea, no vomiting," said Dr. Melody Cobleigh of Rush University Medical Center. "It's a revolutionary way of treating cancer."

Cobleigh helped conduct the key studies of the drug at the Chicago facility.

The FDA approved the new treatment for about 20 percent of breast cancer patients with a form of the disease that is typically more aggressive and less responsive to hormone therapy. These patients have tumors that overproduce a protein known as HER-2. Breast cancer is the second most deadly form of cancer in U.S. women, and is expected to kill more than 39,000 Americans this year, according to the National Cancer Institute.

The approval will help Roche's Genentech unit build on the blockbuster success of Herceptin, which has long dominated the breast cancer marketplace. The drug had sales of roughly $6 billion last year.

Genentech said Friday that Kadcyla will cost $9,800 per month, compared to $4,500 per month for regular Herceptin. The company estimates a full course of Kadcyla, about nine months of medicine, will cost $94,000.

FDA scientists said they approved the drug based on company studies showing Kadcyla delayed the progression of breast cancer by several months. Researchers reported last year that patients treated with the drug lived 9.6 months before death or the spread of their disease, compared with a little more than six months for patients treated with two other standard drugs, Tykerb and Xeloda.

Overall, patients taking Kadcyla lived about 2.6 years, compared with 2 years for patients taking the other drugs.

FDA specifically approved the drug for patients with advanced breast cancer who have already been treated with Herceptin and taxane, a widely used chemotherapy drug. Doctors are not required to follow FDA prescribing guidelines, and cancer researchers say the drug could have great potential in patients with earlier forms of breast cancer

Kadcyla will carry a boxed warning, the most severe type, alerting doctors and patients that the drug can cause liver toxicity, heart problems and potentially death. The drug can also cause severe birth defects and should not be used by pregnant women.

Kadcyla was developed by South San Francisco-based Genentech using drug-binding technology licensed from Waltham, Mass.-based ImmunoGen. The company developed the chemical that keeps the drug cocktail together and is scheduled to receive a $10.5 million payment from Genentech on the FDA decision. The company will also receive additional royalties on the drug's sales.

Shares of ImmunoGen Inc. rose 2 cents to $14.32 in afternoon trading. The stock has ttraded in a 52-wek range of $10.85 to $18.10.

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